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First, Let's Understand the Players Before we can talk about combining them, we have to get an unflinching look at what each of these peptides is and, more importantly, what it isnt

Semaglutide and tirzepatide (2 different GLP-1s) have already been shown to provide several cardiovascular benefits beyond improving blood sugar control

Lauria G, Lombardi R

Any interaction with GABAergic agents, benzodiazepines, or other sedatives is unstudied and theoretically could produce additive CNS depression

The most recent A1C and BMI values, within the year prior, to the new GLP-1 RA prescription were determined and used in the analysis (referred to as baseline values)